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According to Nexcom, the NISE 3500 supports the following:
Obviously designed more for I/O than for hefty internal storage, the NISE 3500 includes a single 2.5-inch bay for SATA hard disk drives. However, external drives may readily be added via the system's two eSATA ports, Nexcom notes.

The device's front panel, shown above left, additionally includes two USB 2.0 ports, along with six LEDs for monitoring system status. The rear panel, above right, offers two gigabit Ethernet ports, four more USB 2.0 ports, and a 44-pin connector for four serial ports (3 RS232, 1 RS232/422/485).
Also around back are VGA and DVI ports, and a DB15 connector for GPIO (four digital inputs and four digital outputs. If GPIO is not required, this space may be used for two optional LVDS ports, Nexcom says. (The company's data sheets imply that only of the system's video outputs may be used simultaneously, but those who have multi-screen applications in mind might want to dig further.)
Meanwhile, a variant known as the NISE 3500M has additional ports on its front panel, as pictured at right. The additions include an HDMI output and three IEEE 1394b connectors, says Nexcom, which chooses to bill this model as "medical certified."
Nexcom's PR release regarding the NISE 3500 says the device has "one PCI and one PCI x1 slot," but the images above imply an either-or situation regarding expansion cards. The device's data sheet says only that PCI expansion cards up to 66.65 inches (169mm) in length are supported.
Further information
Nexcom did not release pricing for the NISE 3500 or 3500M but said the devices will be sampling this month. More information on the devices, including data sheets in PDF format, may be found on the company's website, here and here.
No details of operating system support were given, but the device should, of course, run just about any x86 OS.